Dr. Mark Edwards grew up in Petersburg, Indiana, playing high school basketball before leaving to attend David Lipscomb College in Nashville, Tennessee. He graduated with a Bachelor of Science degree in biology, and was valedictorian of his class.

Dr. Edwards attended the Indiana University School of Medicine receiving his medical degree in 1984. He then moved to Springfield, Illinois, for his general surgery residency program at the Southern Illinois University School of Medicine. During his residency, Dr. Edwards was selected to the Alpha Omega Alpha Honor Society.

He joined Naab Road Surgical Group in July 1989, and since his arrival has been selected four times by the Indianapolis Monthly Magazine as a "Top Doc". Dr. Edwards is board certified by the American Board of Surgery and is a Fellow in the American College of Surgeons. He is also a member of the American Medical Society, Midwest Surgical Society, Society of Laparoendoscopic Surgeons, Indiana State Medical Association, and the Indianapolis Medical Society.

Dr. Edwards and his wife Jane have two children. He enjoys golf and working on his yard.